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Additionally, lifestyle factors play a significant role: weight gain, reduced physical activity, poor dietary adherence, or increased stress can all contribute to worsening glycaemic control, making it appear as though Rybelsus is no longer working
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Linn-Larsson E, Galaev I, Lindahl L, et al
Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity
In the SELECT trial, adverse events leading to permanent discontinuation were reported in 16.6% of semaglutide-treated participants versus 8.2% in the placebo group, which shows that persistence remains a meaningful clinical and commercial issue even in closely monitored study populations
